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Infrastructure for NMR, EM and X-rays for translational research

Rezultaty

Second report on the interaction with industrial parties

Report on the interaction with industrial parties (EMBL-GR)

Delivery of 370 days of access as High-end Data Acquisition to SONNMRLSF at UU
Second report on outreach activities
Start of TA to HT integrated fragment screening in Grenoble

Start of TA to HT integrated fragment screening in Grenoble (EMBL-GR)

Secondary screening of a set of derivatives around an initial hit making use of the EU-OPENSCREEN library
Delivery of 145 days of access to NMR at CEITEC
Reports on feasibility studies on the promising translational targets
Setup for lower background for diffraction data on membrane proteins
Delivery of 100 days of access as Enhanced Support to SONNMRLSF at UU
At least two articles for the general public
Report on Coordination activities with Virtual Research Environments
Storage and queuing facilities at ESRF
120 samples through “Structural Audit”
Report on novel biophysical methods
Hiring a Project Manager
Protocols and tools for using ssNMR to study protein complexes associated with cellular compartments
Report on Coordination activities with PDBe and Elixir
Delivery of 120 samples through the Structural Audit procedure at NKI
Report on a model for future structural biology access in Europe
Delivery of 305 days of High-End Data Acquisition to NMR at BMRZ
TA access to HT crystallization and crystal mounting

TA access to HT crystallization and crystal mounting (EMBL-GR)

Delivery of 75 days of access to Cryo-EM at CSIC
First report on the interaction with industrial parties

Report on the interaction with industrial parties (EMBL-GR)

Report on financial sustainability
Delivery of 2389 hours of access to Beam MX at Diamond
Second report on conferences and meetings with iNEXT representation

Second report on conferences and meetings with iNEXT representation (EMBL-HH)

Report on the organization of TDC workshops
Access to NMR probe(s) optimized for the investigation of membrane proteins (binding studies/,screening)
Start of TA to integrated screening for focused libraries at EMBL-GR/ESRF
Workflow for EM-based determination of membrane protein structures

Workflow for EM-based determination of membrane protein structures (EMBL-HD)

Delivery of 78 days of full service ‘Protein to XTAL’at EMBL-HH
Data management system for ligand and fragment screening, extending ISPyB
Protocols for membrane protein structure determination by solid-state NMR
Protocols for correlative fluorescent labeling of proteins in vitro and in situ
Delivery of 130 days of access to cryo-EM at CEITEC
Second summary report on networking activities

Second summary report on networking activities (EMBL-HH)

Draft sustainability plan
Report on the attendance to EMBO and FEBS meetings

Report on the attendance to EMBO, FEBS and similar meetings

Automatic EM Image Processing workflow in the absence of structural flexibility
Automation of the on-line SEC setups at the partner SAXS beamlines
First summary report on networking activities

First summary report on networking activities (EMBL-HH)

Integrated submission system operational
Protocols and tools for protein interactions in mammalian cells by NMR
Delivery of 144 days of access to Titan KRIO cyro-EM at NeCEN
Delivery of 76 days of full service ‘Protein to SAXS at EMBL-HH
Delivery of 192 supervised access days to EMCF at EMBL-HD
Protocols for data acquisition for correlative CLEXM
Storage and queuing facilities at Diamond
Delivery of 5450 supervised access hours to ALMF at EMBL-HD
Report on comparative analysis of data models in all disciplines and strategy for integration
Delivery of 110 days of access to NMR at RALF-NMR
Delivery of 36 days of accessto Integrated fragment screening by MX at EMBL-GR
Report on the organization of annual user meetings
Delivery of 1555 hours of access to MX beamtime at EMBL-HH
Delivery of 14 days of access to Integrated compound screening (focused libraries) by MX at EMBL-GR
Protocols for RNA sample optimization and DNA/RNA delivery into bacterial and mammalian cells. for in-cell NMR studies
Access to an integrated miniaturized HT-SEC-SAXS set-up

Access to an integrated miniaturized HT-SEC-SAXS set-up (EMBL-HH)

Management Guidelines
Delivery of 70 days of access to Integrated Macromolecular Crystallography service at EMBL-GR
Optimized protocols for reconstitution of membrane proteins

Optimized protocols for reconstitution of membrane proteins (EMBL-HH)

Automated SAXS pipeline for membrane proteins, integrated into ISPyB

Automated SAXS pipeline for membrane proteins, integrated into ISPyB (EMBL-HH)

Automated pipelines for NMR-based structure determination accessible online
Delivery of 10 days of Structural Audit to NMR at BMRZ
Delivery of 2720 hours of access to Beam MX/SAXS at SOLEIL
Start of TA to HT integrated fragment screening at Diamond
Fully automatic screening, large scale X-ray data collection pipelines
Start of TA access to HT fragment screening by NMR
Delivery of 10 days of access as Structural Audit to SONNMRLSF at UU
Delivery of 100 days of Enhanced Support to NMR at BMRZ
Delivery of 212 days of access to NMR at FVB-FMP
Report on demands of the user community
Representation on RI bodies or Committees
Protocols for preparing ssNMR samples in bacterial and mammalian cell fractions and cells
15 structure validation projects through biophysics facility
Characterization of 120 “SAXS x-audit” samples at EMBL-HH
Delivery of 346 days of High-End Data Acquisition to NMR at CERM/CIRMMP
SONICC-based centring of membrane protein crystals
CRIMS support for ligand and fragment screening

CRIMS support for ligand and fragment screening (EMBL-GR)

Data management system for a EM workflows, extending ISPyB
Fragment library distributed to partners
Delivery of 775 hours of access to SAXS beamtime at EMBL-HH
Summary report on networking activities with industry

Summary report on networking activities with industry (EMBL-GR)

First report on outreach activities
First report on conferences and meetings with iNEXT representation

First report on conferences and meetings with iNEXT representation (EMBL-HH)

Delivery of access for 60 mail-in SAXS sessions at Diamond
Delivery of 30 samples analysed for Structural Audit at CSIC

Delivery of 30 samples analysed for Structural Audit at CSIC

Optimized workflows for ligand screening by NMR
Best practice workflows for cryo electron tomography specimen preparation
Fluorophore knock in cell lines for structural studies

Fluorophore knock in cell lines for structural studies (EMBL-HD)

Protocols for cooperation with ESFRI BMS RIs
5 integrated structure validation projects through combined access in biophysics and imaging
Delivery of access to 10 screening campaigns at Diamond
Delivery of 20 projects for biophysical characterisation at NKI
Delivery of 10 days of Structural Audit to NMR at CERM/CIRMMP
Delivery of 750 hours of access to the BioMAX beamline at MAXIV
Delivery of 100 days of Enhanced Support to NMR at CERM/CIRMMP
15 structure validation projects through advanced imaging facility
Delivery of 110 days of access to cryo-EM at Diamond

Publikacje

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

Autorzy: Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Opublikowane w: Nature Biotechnology, Numer 35(11), 2017, Strona(/y) 1094-1101, ISSN 1087-0156
Wydawca: Nature Publishing Group
DOI: 10.1038/nbt.3994

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

Autorzy: Paul Huter, Stefan Arenz, Lars V. Bock, Michael Graf, Jan Ole Frister, Andre Heuer, Lauri Peil, Agata L. Starosta, Ingo Wohlgemuth, Frank Peske, Jiří Nováček, Otto Berninghausen, Helmut Grubmüller, Tanel Tenson, Roland Beckmann, Marina V. Rodnina, Andrea C. Vaiana, Daniel N. Wilson
Opublikowane w: Molecular Cell, Numer 68/3, 2017, Strona(/y) 515-527.e6, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2017.10.014

Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy

Autorzy: Stefano Giuntini, Evita Balducci, Linda Cerofolini, Enrico Ravera, Marco Fragai, Francesco Berti, Claudio Luchinat
Opublikowane w: Angewandte Chemie International Edition, Numer 56/47, 2017, Strona(/y) 14997-15001, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709274

Structural Snapshots of α-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases

Autorzy: David Albesa-Jové, M. Ángela Sainz-Polo, Alberto Marina, Marcelo E. Guerin
Opublikowane w: Angewandte Chemie International Edition, Numer 56/47, 2017, Strona(/y) 14853-14857, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201707922

Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction

Autorzy: Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 140/6, 2017, Strona(/y) 1728-1731.e10, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2017.06.016

Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding

Autorzy: Florian Lehner, Denis Kudlinzki, Christian Richter, Henrike M. Müller-Werkmeister, Katharina B. Eberl, Jens Bredenbeck, Harald Schwalbe, Robert Silvers
Opublikowane w: ChemBioChem, Numer 18/23, 2017, Strona(/y) 2340-2350, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201700437

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

Autorzy: Enrico Luchinat, Letizia Barbieri, Lucia Banci
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-17815-y

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Autorzy: Pau Martin-Malpartida, Marta Batet, Zuzanna Kaczmarska, Regina Freier, Tiago Gomes, Eric Aragón, Yilong Zou, Qiong Wang, Qiaoran Xi, Lidia Ruiz, Angela Vea, José A. Márquez, Joan Massagué, Maria J. Macias
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02054-6

Structure of outer membrane protein G in lipid bilayers

Autorzy: Joren S. Retel, Andrew J. Nieuwkoop, Matthias Hiller, Victoria A. Higman, Emeline Barbet-Massin, Jan Stanek, Loren B. Andreas, W. Trent Franks, Barth-Jan van Rossum, Kutti R. Vinothkumar, Lieselotte Handel, Gregorio Giuseppe de Palma, Benjamin Bardiaux, Guido Pintacuda, Lyndon Emsley, Werner Kühlbrandt, Hartmut Oschkinat
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02228-2

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Autorzy: Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Opublikowane w: Nature Communications, Numer 8/1, 2017, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02313-6

Atomic structural details of a protein grafted onto gold nanoparticles

Autorzy: Stefano Giuntini, Linda Cerofolini, Enrico Ravera, Marco Fragai, Claudio Luchinat
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-18109-z

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Autorzy: Miguel Romano-Moreno, Adriana L. Rojas, Chad D. Williamson, David C. Gershlick, María Lucas, Michail N. Isupov, Juan S. Bonifacino, Matthias P. Machner, Aitor Hierro
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 114/52, 2017, Strona(/y) E11151-E11160, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1715361115

Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins

Autorzy: Linda Cerofolini, Tommaso Staderini, Stefano Giuntini, Enrico Ravera, Marco Fragai, Giacomo Parigi, Roberta Pierattelli, Claudio Luchinat
Opublikowane w: JBIC Journal of Biological Inorganic Chemistry, Numer 23/1, 2018, Strona(/y) 71-80, ISSN 0949-8257
Wydawca: Springer Verlag
DOI: 10.1007/s00775-017-1511-y

Intracellular metal binding and redox behavior of human DJ-1

Autorzy: Letizia Barbieri, Enrico Luchinat, Lucia Banci
Opublikowane w: JBIC Journal of Biological Inorganic Chemistry, Numer 23/1, 2018, Strona(/y) 61-69, ISSN 0949-8257
Wydawca: Springer Verlag
DOI: 10.1007/s00775-017-1509-5

Dynamic control of RSK complexes by phosphoswitch-based regulation

Autorzy: Gergő Gógl, Beáta Biri-Kovács, Ádám L. Póti, Henrietta Vadászi, Bálint Szeder, Andrea Bodor, Gitta Schlosser, András Ács, Lilla Turiák, László Buday, Anita Alexa, László Nyitray, Attila Reményi
Opublikowane w: The FEBS Journal, Numer 285/1, 2018, Strona(/y) 46-71, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.14311

Combined 1H-Detected Solid-State NMR Spectroscopy and Electron Cryotomography to Study Membrane Proteins across Resolutions in Native Environments

Autorzy: Baker LA, Sinnige T, Schellenberger P, de Keyzer J, Siebert CA, Driessen AJM, Baldus M, Grünewald K
Opublikowane w: Structure, Numer 26/1, 2018, Strona(/y) 161-170.e3, ISSN 0969-2126
Wydawca: Elsevier

Structural basis of RNA polymerase III transcription initiation

Autorzy: Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron, Edward Morris, Alessandro Vannini
Opublikowane w: Nature, Numer 553/7688, 2018, Strona(/y) 301-306, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature25441

1 H NMR Spectroscopy of [FeFe] Hydrogenase: Insight into the Electronic Structure of the Active Site

Autorzy: Sigrun Rumpel, Enrico Ravera, Constanze Sommer, Edward Reijerse, Christophe Farès, Claudio Luchinat, Wolfgang Lubitz
Opublikowane w: Journal of the American Chemical Society, Numer 140/1, 2017, Strona(/y) 131-134, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.7b11196

Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain

Autorzy: The Quyen Nguyen, Mélanie Chenon, Fernando Vilela, Christophe Velours, Magali Aumont-Nicaise, Jessica Andreani, Paloma F. Varela, Paola Llinas, Julie Ménétrey
Opublikowane w: PLOS ONE, Numer October 16, 2017, 2017, Strona(/y) 1-20, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0186354.s004

Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research

Autorzy: Flayhan A, Mertens HDT, Ural-Blimke Y, Martinez Molledo M, Svergun DI, Löw C
Opublikowane w: Structure, Numer 26, 2018, Strona(/y) 345-355, ISSN 0969-2126
Wydawca: Cell Press
DOI: 10.1016/j.str.2018.01.007

CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data

Autorzy: Alejandro Panjkovich, Dmitri I Svergun
Opublikowane w: Bioinformatics, Numer 28 December 2017, 2017, Strona(/y) 1-3, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btx846

Automated harvesting and processing of protein crystals through laser photoablation

Autorzy: Ulrich Zander, Guillaume Hoffmann, Irina Cornaciu, Jean-Pierre Marquette, Gergely Papp, Christophe Landret, Gaël Seroul, Jérémy Sinoir, Martin Röwer, Frank Felisaz, Sonia Rodriguez-Puente, Vincent Mariaule, Peter Murphy, Magali Mathieu, Florent Cipriani, José Antonio Márquez
Opublikowane w: Acta Crystallographica Section D Structural Biology, Numer 72/4, 2016, Strona(/y) 454-466, ISSN 2059-7983
Wydawca: John Wiley & Sons Ltd
DOI: 10.1107/S2059798316000954

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

Autorzy: Yi-Han Lin, María Lucas, Timothy R. Evans, Guillermo Abascal-Palacios, Alexandra G. Doms, Nicole A. Beauchene, Adriana L. Rojas, Aitor Hierro, Matthias P. Machner
Opublikowane w: PLOS Pathogens, Numer 14/2, 2018, Strona(/y) e1006897, ISSN 1553-7374
Wydawca: PLOS
DOI: 10.1371/journal.ppat.1006897

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Autorzy: Florian Delbart, Marijke Brams, Fabian Gruss, Sam Noppen, Steve Peigneur, Sandro Boland, Patrick Chaltin, Jose Brandao-Neto, Frank von Delft, Wouter G. Touw, Robbie P. Joosten, Sandra Liekens, Jan Tytgat, Chris Ulens
Opublikowane w: Journal of Biological Chemistry, Numer 293/7, 2018, Strona(/y) 2534-2545, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M117.815316

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells

Autorzy: Simon Dzatko, Michaela Krafcikova, Robert Hänsel-Hertsch, Tomas Fessl, Radovan Fiala, Tomas Loja, Daniel Krafcik, Jean-Louis Mergny, Silvie Foldynova-Trantirkova, Lukas Trantirek
Opublikowane w: Angewandte Chemie International Edition, Numer 57/8, 2018, Strona(/y) 2165-2169, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201712284

A family of unconventional deubiquitinases with modular chain specificity determinants

Autorzy: Thomas Hermanns, Christian Pichlo, Ilka Woiwode, Karsten Klopffleisch, Katharina F. Witting, Huib Ovaa, Ulrich Baumann, Kay Hofmann
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-03148-5

Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12

Autorzy: Sven Falke, Karsten Dierks, Clement Blanchet, Melissa Graewert, Florent Cipriani, Rob Meijers, Dmitri Svergun, Christian Betzel
Opublikowane w: Journal of Synchrotron Radiation, Numer 25/2, 2018, Strona(/y) 361-372, ISSN 1600-5775
Wydawca: IUCr
DOI: 10.1107/S1600577517017568

Homology-based hydrogen bond information improves crystallographic structures in the PDB

Autorzy: Bart van Beusekom, Wouter G. Touw, Mahidhar Tatineni, Sandeep Somani, Gunaretnam Rajagopal, Jinquan Luo, Gary L. Gilliland, Anastassis Perrakis, Robbie P. Joosten
Opublikowane w: Protein Science, Numer 27/3, 2018, Strona(/y) 798-808, ISSN 0961-8368
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.3353

Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation

Autorzy: Shu Zhou, Pontus Pettersson, Jingjing Huang, Johannes Sjöholm, Dan Sjöstrand, Régis Pomès, Martin Högbom, Peter Brzezinski, Lena Mäler, Pia Ädelroth
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 115/12, 2018, Strona(/y) 3048-3053, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1712061115

Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.

Autorzy: Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Löw C
Opublikowane w: Structure, Numer Mar 6;26(3), 2018, Strona(/y) 467-476, ISSN 0969-2126
Wydawca: Elsevier

A multidisciplinary study of 3-(β- d -glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Autorzy: Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C.V. Stamati, Thomas A. Barkas, Eszter Szennyes, Éva Bokor, Katalin E. Szabó, George A. Stravodimos, Ádám Sipos, Tibor Docsa, Pál Gergely, Colin Moffatt, Myrto S. Patraskaki, Maria C. Kokolaki, Alkistis Gkerdi, Vassiliki T. Skamnaki, Demetres D. Leonidas, László Somsák, Joseph M. Hayes
Opublikowane w: European Journal of Medicinal Chemistry, Numer 147, 2018, Strona(/y) 266-278, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2018.01.095

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor

Autorzy: Kinga Nyíri, Haydyn D. T. Mertens, Borbála Tihanyi, Gergely N. Nagy, Bianka Kőhegyi, Judit Matejka, Matthew J. Harris, Judit E. Szabó, Veronika Papp-Kádár, Veronika Németh-Pongrácz, Olivér Ozohanics, Károly Vékey, Dmitri I. Svergun, Antoni J. Borysik, Beáta G. Vértessy
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-22145-8

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

Autorzy: Verity A. Jackson, Dimphna H. Meijer, Maria Carrasquero, Laura S. van Bezouwen, Edward D. Lowe, Colin Kleanthous, Bert J. C. Janssen, Elena Seiradake
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-03460-0

Structural changes of TasA in biofilm formation of Bacillus subtilis

Autorzy: Anne Diehl, Yvette Roske, Linda Ball, Anup Chowdhury, Matthias Hiller, Noel Molière, Regina Kramer, Daniel Stöppler, Catherine L. Worth, Brigitte Schlegel, Martina Leidert, Nils Cremer, Natalja Erdmann, Daniel Lopez, Heike Stephanowitz, Eberhard Krause, Barth-Jan van Rossum, Peter Schmieder, Udo Heinemann, Kürşad Turgay, Ümit Akbey, Hartmut Oschkinat
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 115/13, 2018, Strona(/y) 3237-3242, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1718102115

1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region

Autorzy: Julien Marquevielle, M. V. Vasantha Kumar, Jean-Louis Mergny, Gilmar F. Salgado
Opublikowane w: Biomolecular NMR Assignments, Numer 12/1, 2018, Strona(/y) 123-127, ISSN 1874-2718
Wydawca: Springer Verlag
DOI: 10.1007/s12104-017-9793-0

A General Small-Angle X-ray Scattering-Based Screening Protocol Validated for Protein–RNA Interactions

Autorzy: Po-chia Chen, Pawel Masiewicz, Vladimir Rybin, Dmitri Svergun, Janosch Hennig
Opublikowane w: ACS Combinatorial Science, Numer 20/4, 2018, Strona(/y) 197-202, ISSN 2156-8952
Wydawca: American Chemical Society
DOI: 10.1021/acscombsci.8b00007

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A

Autorzy: Anna Niesteruk, Marie Hutchison, Sridhar Sreeramulu, Hendrik R.A. Jonker, Christian Richter, Rupert Abele, Christoph Bock, Harald Schwalbe
Opublikowane w: FEBS Letters, Numer 592/7, 2018, Strona(/y) 1233-1245, ISSN 0014-5793
Wydawca: Elsevier BV
DOI: 10.1002/1873-3468.13022

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

Autorzy: Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-03942-1

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Autorzy: Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04114-x

Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP

Autorzy: Yury B. Slonimskiy, Eugene G. Maksimov, Evgeny P. Lukashev, Marcus Moldenhauer, Cy M. Jeffries, Dmitri I. Svergun, Thomas Friedrich, Nikolai N. Sluchanko
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Numer 1859/5, 2018, Strona(/y) 382-393, ISSN 0005-2728
Wydawca: Elsevier BV
DOI: 10.1016/j.bbabio.2018.03.001

Integrated beamline control and data acquisition for small-angle X-ray scattering at the P12 BioSAXS beamline at PETRAIII storage ring DESY

Autorzy: Nelly R. Hajizadeh, Daniel Franke, Dmitri I. Svergun
Opublikowane w: Journal of Synchrotron Radiation, Numer 25/3, 2018, Strona(/y) 906-914, ISSN 1600-5775
Wydawca: IUCr
DOI: 10.1107/S1600577518005398

Consensus Bayesian assessment of protein molecular mass from solution X-ray scattering data

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Structural insights into the molecular function of human [2Fe-2S] BOLA1-GRX5 and [2Fe-2S] BOLA3-GRX5 complexes

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A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone

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Paramagnetic Properties of a Crystalline Iron–Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy

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A Novel Approach to Data Collection for Difficult Structures: Data Management for Large Numbers of Crystals with the BLEND Software

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