Skip to main content
European Commission logo
polski polski
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Zawartość zarchiwizowana w dniu 2024-05-30

Deciphering the molecular basis of regulatory T cell suppression

Cel

Regulatory T cells (TREG) comprise a subset of CD4+ T cells that maintain immunological tolerance by suppressing immune activation in a dominant manner. TREG helps shaping the immune responses to autoantigens, alloantigens, tumors, pathogens and allergens, and are thus considered a therapeutical target in a large variety of diseases. One aspect of TREG biology that remains poorly understood is what molecular program(s) are induced in cells that are being actively suppressed by TREG. The specific aims described below are designed to provide a better understanding of the molecular changes that occur as a result of TREG-mediated suppression and determine if the biochemical pathways altered by TREG-mediated suppression can be exploited for therapeutical purposes.

1. Characterize the molecular changes that occur in CD4+ T cells and dendritic cells that are being suppressed by TREG using gene profiling and cell signaling experimental approaches.

2. Evaluate the importance and therapeutical potential of genes with an expression
profile altered by TREG-mediated suppression in animal models of human diseases.

Słowa kluczowe

Zaproszenie do składania wniosków

FP7-PEOPLE-IRG-2008
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

KAROLINSKA INSTITUTET
Wkład UE
€ 100 000,00
Adres
Nobels Vag 5
17177 Stockholm
Szwecja

Zobacz na mapie

Region
Östra Sverige Stockholm Stockholms län
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Caroline Hamilton (Ms.)
Linki
Koszt całkowity
Brak danych