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Zawartość zarchiwizowana w dniu 2024-06-18

Non-invasive imaging of brain function and disease by pulsed near infrared light

Cel

The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography) provide 3D anatomical, functional or pathological information with spatial resolution in the millimetre range. However, these methods cannot be applied continuously or at the bedside. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner. The devices will be portable and comparably inexpensive and can be applied in adults and in children. Time-domain techniques are acknowledged as offering superior information content and sensitivity compared to other optical methods, allowing for separation between contributions of surface tissues (skin and skull) and brain tissue. Time-domain imaging can also differentiate between the effects of scatter and those of absorption.The consortium plans major developments in technology and data analysis that will enhance time-domain diffuse optical imaging with respect to spatial resolution, sensitivity, robustness of quantification as well as performance of related instruments in clinical diagnosis and monitoring. The diagnostic value of time-domain diffuse optical imaging will be assessed by clinical pilot studies addressing specific neurological disorders, in comparison with established neurophysiological and neuroimaging techniques. Perspectives regarding clinical application of time-domain diffuse optical brain imaging will be estimated and a reliable basis for a potential commercialisation of this novel technique by European system manufacturers will be created.

Zaproszenie do składania wniosków

FP7-HEALTH-2007-A
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

POLITECNICO DI MILANO
Wkład UE
€ 1 120 222,00
Adres
PIAZZA LEONARDO DA VINCI 32
20133 Milano
Włochy

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Region
Nord-Ovest Lombardia Milano
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Rinaldo Cubeddu (Prof.)
Linki
Koszt całkowity
Brak danych

Uczestnicy (13)