Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 | INNODIA | Project | Results | H2020 | CORDIS

Rezultaty

Characterization of the role for post- translational modifications, alternative splicing and endoplasmic reticulum stress for β-cell recognition by the immune system

Migration

Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D

Migration

Relationships between immune response/regulation, genome, transcriptome, epigenome, proteome, metabolome and metagenome

Migration

A comprehensive pan-European research network for the study of the aetiology and prevention of T1D

Migration

Successful start-up of the project - Kick Off Meeting

Migration

EUnPOD functioning

Migration

Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D

Migration

Imaging tool for -cell inflammation/death

Migration

Development of novel approaches for in vivo β-cell imaging

Migration

Plan for access to the CTN by third parties

Migration

Modelling the role for T1D candidate genes in the beta-cell-immune system dialog, and using this information to develop novel approaches to prevent β-cell death in diabetes.

Migration

Novel models of the cross talk between human β-cells and the human system in vitro

Migration

Discovery analysis of novel biomarkers in β- cell-omics, immunomics, genomics, transcriptomics, proteomics, metabolomics and lipidomics

Migration

Launch public website

Migration

Publikacje

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Autorzy: Alexia Carré, Sarah J. Richardson, Etienne Larger, Roberto Mallone
Opublikowane w: Diabetologia, Numer 64/1, 2021, Strona(/y) 15-25, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Autorzy: Mallone R, You S.
Opublikowane w: Diabetes, Numer 70(6), 2021, Strona(/y) 1247-1249, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/dbi21-0011

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.

Autorzy: Martens PJ, Gysemans C, Mathieu C.
Opublikowane w: The Journal of endocrinology, Numer 249(2), 2021, Strona(/y) T1-T11, ISSN 0022-0795
Wydawca: Society for Endocrinology
DOI: 10.1530/joe-20-0552

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Autorzy: Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Opublikowane w: iScience, 2022, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2021.103653

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Autorzy: Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Opublikowane w: NAR genomics and bioinformatics, Numer 4(4), 2022, Strona(/y) lqac084, ISSN 2631-9268
Wydawca: [Oxford] : Oxford University Press, [2019]-
DOI: 10.1093/nargab/lqac084

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Autorzy: Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Opublikowane w: Frontiers in molecular biosciences., Numer 8:689799, 2021, ISSN 2296-889X
Wydawca: Frontiers Media S.A.,
DOI: 10.3389/fmolb.2021.689799

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Autorzy: Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Opublikowane w: Diabetologia, Numer 66(7), 2023, Strona(/y) 1273-1288, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-023-05912-9

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Autorzy: Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Opublikowane w: Diabetes., Numer 72(1), 2022, Strona(/y) 85-96, ISSN 1939-327X
Wydawca: [New York, American Diabetes Association]
DOI: 10.2337/db22-0191

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autorzy: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Opublikowane w: Nature Reviews Endocrinology, Numer 16/7, 2020, Strona(/y) 349-362, ISSN 1759-5029
Wydawca: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

Autorzy: Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, Elo LL, Lahesmaa R; INNODIA consortium
Opublikowane w: Diabetologia, Numer 66(11), 2023, Strona(/y) 1983-1996, ISSN 0012-186X
Wydawca: Springer Verlag
DOI: 10.1007/s00125-023-05974-9

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Autorzy: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Opublikowane w: Cell Reports, Numer 31/1, 2020, Strona(/y) 107469, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.03.033

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Autorzy: Farooq Syed, Sarah A. Tersey, Jean-Valery Turatsinze, Jamie L. Felton, Nicole Jiyun Kang, Jennifer B. Nelson, Emily K. Sims, Mathieu Defrance, Martin Bizet, Francois Fuks, Miriam Cnop, Marco Bugliani, Piero Marchetti, Anette-Gabriele Ziegler, Ezio Bonifacio, Bobbie-Jo Webb-Robertson, Appakalai N. Balamurugan, Carmella Evans-Molina, Decio L. Eizirik, Kieren J. Mather, Silva Arslanian, Raghavendra G
Opublikowane w: Clinical Epigenetics, Numer 12/1, 2020, Strona(/y) 116, ISSN 1868-7075
Wydawca: Springer Verlag
DOI: 10.1186/s13148-020-00906-5

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Autorzy: Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew N. Wakeling, Federica Fantuzzi, Kashyap Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas W. Laver, Matthew B. Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Nuri Ozbek, Edip Unal, Ruken Yıldırım, Tusha
Opublikowane w: Journal of Clinical Investigation, Numer 130/12, 2020, Strona(/y) 6338-6353, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.

Autorzy: Colli ML, Szymczak F, Eizirik DL.
Opublikowane w: Frontiers in endocrinology., 2020, Strona(/y) 11:568446, ISSN 1664-2392
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Area Deprivation and Regional Disparities in Treatment and Outcome Quality of 29,284 Pediatric Patients With Type 1 Diabetes in Germany: A Cross-sectional Multicenter DPV Analysis

Autorzy: Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
Opublikowane w: Diabetes Care, Numer 41/12, 2018, Strona(/y) 2517-2525, ISSN 0149-5992
Wydawca: American Diabetes Association
DOI: 10.2337/dc18-0724

RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures

Autorzy: Piron A, Szymczak F, Papadopoulou T, Alvelos MI, Defrance M, Lenaerts T, Eizirik DL, Cnop M
Opublikowane w: Life science alliance, Numer 7(2), 2023, Strona(/y) e202302203, ISSN 2575-1077
Wydawca: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302203

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Autorzy: Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Opublikowane w: The Journal of biological chemistry., Numer 298, 2022, Strona(/y) 7, ISSN 1083-351X
Wydawca: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Preventing type 1 diabetes in childhood.

Autorzy: Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Opublikowane w: Science, Numer 373(6554), 2021, Strona(/y) 506-510, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Autorzy: Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Opublikowane w: Auto- immunity highlights., Numer 12(1), 2021, Strona(/y) 6, ISSN 2038-0305
Wydawca: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Autorzy: Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Opublikowane w: International journal of molecular sciences., Numer 23(13), 2022, Strona(/y) 7435, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Autorzy: Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Opublikowane w: Frontiers in immunology., Numer 12:744509, 2021, ISSN 1664-3224
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.744509

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes

Autorzy: Bart O Roep
Opublikowane w: Frontiers in immunology, Numer 14, 2023, Strona(/y) 14:1112858, ISSN 1664-3224
Wydawca: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2023.1112858

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Autorzy: Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Opublikowane w: Frontiers in immunology, Numer 12:683091, 2021, ISSN 1664-3224
Wydawca: Frontiers Research Foundation
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The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Autorzy: Mallone R, Halliez C, Rui J, Herold KC.
Opublikowane w: Diabetes, Numer 71(8), 2022, Strona(/y) 1603-1610, ISSN 1939-327X
Wydawca: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Autorzy: Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Opublikowane w: Cells, Numer 11(15), 2022, Strona(/y) 2465, ISSN 2073-4409
Wydawca: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Autorzy: Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
Opublikowane w: European journal of immunology., Numer 52(3), 2022, Strona(/y) 372–388., ISSN 1521-4141
Wydawca: Weinheim, Verlag Chemie GmbH.
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The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes

Autorzy: Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Opublikowane w: Diabetologia, Numer 66(6), 2023, Strona(/y) 1129–1141, ISSN 1432-0428
Wydawca: Berlin Springer Verlag
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ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Autorzy: Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Opublikowane w: Frontiers in endocrinology, Numer 13, 2022, Strona(/y) 1058345, ISSN 1664-2392
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Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism

Autorzy: Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W. Holl
Opublikowane w: Orphanet Journal of Rare Diseases, Numer 13/1, 2018, ISSN 1750-1172
Wydawca: BioMed Central
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Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Autorzy: Perez-Hernandez J, Chiurchiu V, Perruche S, You S
Opublikowane w: Frontiers in immunology, Numer 12, 2021, Strona(/y) 768133, ISSN 1664-3224
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Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Autorzy: Arif S, Domingo-Vila C, Pollock E, Christakou E, Williams E, Tree T.
Opublikowane w: Frontiers in immunology, Numer 14, 2023, Strona(/y) 14:1183909, ISSN 1664-3224
Wydawca: Lausanne : Frontiers Research Foundation
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Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Autorzy: Carré A, Mallone R.
Opublikowane w: Frontiers in immunology., Numer 12:639682, 2020, ISSN 1664-3224
Wydawca: Frontiers Research Foundation
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The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Autorzy: Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
Opublikowane w: Journal of Clinical Medicine, Numer 11(3), 2022, Strona(/y) 663, ISSN 2077-0383
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Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case‐control study

Autorzy: Stefanie Lanzinger, Alena Welters, Angelika Thon, Katja Konrad, Thomas Kapellen, Jürgen Grulich‐Henn, Dirk Raddatz, Reinhard W. Holl
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Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Autorzy: Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
Opublikowane w: Frontiers in immunology., Numer 13, 2022, Strona(/y) 886736, ISSN 1664-3224
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A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Autorzy: Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Opublikowane w: Islwts, Numer 13(3-4), 2021, Strona(/y) 51-65, ISSN 1938-2014
Wydawca: Landes Bioscience
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Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Autorzy: Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Opublikowane w: Frontiers in endocrinology., Numer 13, 2022, Strona(/y) 908248, ISSN 1664-2392
Wydawca: Lausanne : Frontiers Research Foundation
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Autorzy: Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
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Wydawca: Nature Publishing Company
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Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Autorzy: Vig S, Lambooij JM, Zaldumbide A, Guigas B.
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Wydawca: Frontiers Research Foundation
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Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Autorzy: Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
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Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

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Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Autorzy: Samassa F, Mallone R.
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Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Autorzy: Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
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Wydawca: American Diabetes Association
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The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Autorzy: Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
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Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Autorzy: Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Autorzy: Eizirik DL, Szymczak F, Mallone R.
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Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Autorzy: Diego Balboa, Jonna Saarimäki-Vire, Timo Otonkoski
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Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39)

Autorzy: Collado Camps E, van Lith SAM, Kip A, Frielink C, Joosten L, Brock R, Gotthardt M.
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SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

Autorzy: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Guido Sebastiani, Francesco Dotta
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Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

Autorzy: Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
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Epitope-based precision immunotherapy of Type 1 diabetes

Autorzy: Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
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Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction

Autorzy: Pugliese LA, De Lorenzi V, Bernardi M, Ghignoli S, Tesi M, Marchetti P, Pesce L, Cardarelli F
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Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

Autorzy: Bart O Roep, Daniel C S Wheeler, Mark Peakman
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Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

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