Reaching the effects of gastric bypass on diabetes and obesity without surgery

Informations projet

BYPASSWITHOUTSURGERY

N° de convention de subvention: 695069

DOI 10.3030/695069

Projet clôturé

Date de signature de la CE 12 Decembre 2016

Date de début 1 Janvier 2017

Date de fin 30 Juin 2023

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total € 2 500 000,00

Contribution de l’UE € 2 500 000,00

Coordonné par

KOBENHAVNS UNIVERSITET
Denmark

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Publications

Peer reviewed articles (49)

Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R–dependent manner

Auteurs: Jepsen SL, Albrechtsen NJW, Windeløv JA, Galsgaard KD, Hunt JE, Farb TB, Kissow H, Pedersen J, Deacon CF, Martin RE, Holst JJ
Publié dans: JCI Insight, 2021, ISSN 2379-3708
Éditeur: JCI insight
DOI: 10.1172/jci.insight.143228

Novel agonist- and antagonist-based radioligands for the GLP-2 receptor - useful tools for studies of basic GLP-2R pharmacology

Auteurs: Sarina Gadgaard; Wijnand J.C. van der Velden; Wijnand J.C. van der Velden; Sine P. Schiellerup; Jenna Hunt; Maria Buur Nordskov Gabe; Johanne Agerlin Windeløv; Geke Aline Boer; Hannelouise Kissow; Cathrine Ørskov; Jens J. Holst; Bolette Hartmann; Mette M. Rosenkilde
Publié dans: British Journal of Pharmacology, Numéro 1, 2021, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.15766

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion.

Auteurs: Kuhre RE, Modvig IM, Jepsen SL, Kizilkaya HS, Bæch-Laursen C, Smith CA, Reimann F, Gribble FM, Rosenkilde MM, Holst JJ.
Publié dans: Front Endocrinol (Lausanne), 2021, ISSN 1664-2392
Éditeur: Frontiers of Endocrinology
DOI: 10.3389/fendo.2021.690387

Follistatin secretion is enhanced by protein, but not glucose or fat ingestion, in obese persons independently of previous gastric bypass surgery

Auteurs: Bojsen-Møller KN, Svane MS, Jensen CZ, Kjeldsen SAS, Holst JJ, Wewer Albrechtsen NJ, Madsbad S.
Publié dans: Am J Physiol Gastrointest Liver Physiol, 2021, ISSN 0193-1857
Éditeur: American Physiological Society
DOI: 10.1152/ajpgi.00396.2020

Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass.

Auteurs: Isabella Jonsson; Kirstine N. Bojsen-Møller; Kirstine N. Bojsen-Møller; Viggo B. Kristiansen; Simon Veedfald; Nicolai J. Wewer Albrechtsen; Nicolai J. Wewer Albrechtsen; Nicolai J. Wewer Albrechtsen; Trine R. Clausen; Rune E. Kuhre; Rune E. Kuhre; Jens F. Rehfeld; Jens J. Holst; Sten Madsbad; Sten Madsbad; Maria S. Svane; Maria S. Svane; Maria S. Svane
Publié dans: Frontiers in Endocrinology, Vol 12 (2021), Numéro 1, 2021, ISSN 1664-2392
Éditeur: Frontiers in Endocrinology
DOI: 10.3389/fendo.2021.681116

Postprandial secretion of follistatin after gastric bypass surgery and sleeve gastrectomy

Auteurs: Richter MM, Svane MS, Kristiansen VB, Holst JJ, Madsbad S, Bojsen-Møller KN.
Publié dans: Peptides, 2019, ISSN 0196-9781
Éditeur: Elsevier BV
DOI: 10.1016/j.peptides.2023.170978

Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery

Auteurs: Christian Zinck Jensen; Kirstine N. Bojsen-Møller; Maria S. Svane; Line Marie Broksø Holst; Kjeld Hermansen; Bolette Hartmann; Nicolai J. Wewer Albrechtsen; Rune E. Kuhre; Viggo B. Kristiansen; Jens F. Rehfeld; Trine R. Clausen; Jens J. Holst; Sten Madsbad
Publié dans: Nutrient sensing, Nutrition and Metabolism, Numéro 1, 2020, ISSN 1548-9213
Éditeur: American Physiological Society
DOI: 10.1152/ajpgi.00265.2019

CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in the rat colon.

Auteurs: Ida M. Modvig; C. Christiansen; Jens F. Rehfeld; Jens J. Holst; Simon Veedfald
Publié dans: Physiological Reports, Numéro 1, 2020, ISSN 2051-817X
Éditeur: Wiley
DOI: 10.14814/phy2.14352

Intestinal sensing and handling of dietary lipids in gastric bypass- operated patients and matched controls

Auteurs: Martinussen C, Dirksen C, Bojsen-Møller KN, Svane MS, Carlsson ER, Hartmann B, Clausen TR, Veedfald S, Kristiansen VB, Rehfeld JF, Hansen HS, Holst JJ, Madsbad S.
Publié dans: Am J Clin Nutr, 2020, ISSN 1938-3207
Éditeur: American Journal of Clinical Nutrition
DOI: 10.1093/ajcn/nqz272

l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels

Auteurs: Ida Marie Modvig, Mark M. Smits, Katrine Douglas Galsgaard, Anna Pii Hjrne, Anna Katarzyna Drzazga, Mette Marie Rosenkilde, Jens Juul Holst
Publié dans: Nutrition & Diabetes, Numéro 14, 2024, ISSN 2044-4052
Éditeur: Nutrition and Diabetes
DOI: 10.1038/s41387-024-00303-4

Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty

Auteurs: Svane MS, Øhrstrøm CC, Plamboeck A, Jørgensen NB, Bojsen-Møller KN, Dirksen C, Martinussen C, Vilsbøll T, Hartmann B, Deacon CF, Kristiansen VB, Knop FK, Svendsen LB, Madsbad S, Holst JJ, Veedfald S.
Publié dans: Neurogastroenterol Motility, 2022, ISSN 2093-0879
Éditeur: Korean Society of Neurogastroenterology and Motility
DOI: 10.1111/nmo.14210

Incretin Hormones and Type 2 Diabetes – Mechanistic Insights and Therapeutic Approaches

Auteurs: Geke Aline Boer; Jens J. Holst
Publié dans: https://www.preprints.org/manuscript/202011.0684/v1, Numéro 1, 2020, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology9120473

Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy

Auteurs: Nora Hedbck, Marie-Louise Dichman, Morten Hinds, Carsten Dirksen, Nils Brun Jrgensen, Kirstine Nyvold Bojsen-Mller, Viggo B. Kristiansen, Jens F. Rehfeld, Bolette Hartmann, Jens Juul Holst, Maria Saur Svane, Sten Madsbad
Publié dans: American Journal of Physiology-Endocrinology and Metabolism, Numéro 327, 2024, Page(s) E396-E410, ISSN 0193-1849
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00177.2024

The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

Auteurs: Hindsø M, Hedbäck N, Svane MS, Møller A, Martinussen C, Jørgensen NB, Dirksen C, Gasbjerg LS, Kristiansen VB, Hartmann B, Rosenkilde MM, Holst JJ, Madsbad S, Bojsen-Møller KN
Publié dans: Diabetes, 2023, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db22-0568

Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight.

Auteurs: Svane MS, Johannesen HH, Hansen AE, Martinussen C, Bojsen-Møller KN, Hansen ML, Deacon CF, Keller SH, Klausen TL, Loft A, Kjaer A, Löfgren J, Madsbad S, Holst JJ, Wewer Albrechtsen NJ.
Publié dans: Int J Obes, 2022, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-022-01207-y

Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice.

Auteurs: Daniel B. Andersen; Kaare V. Grunddal; Jens Pedersen; Rune E. Kuhre; Mari L. Lund; Jens J. Holst; Cathrine Ørskov
Publié dans: Endocrinology, Numéro 1, 2021, ISSN 0013-7227
Éditeur: The Endocrine Society
DOI: 10.1210/endocr/bqaa246

Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays

Auteurs: Geke Aline Boer; Bolette Hartmann; Jens J. Holst
Publié dans: Peptides, Numéro 1, 2021, ISSN 0196-9781
Éditeur: Elsevier BV
DOI: 10.1016/j.peptides.2020.170457

Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine.

Auteurs: Ida M. Modvig; Daniel B. Andersen; Kaare V. Grunddal; Rune E. Kuhre; Christoffer Martinussen; C. Christiansen; Cathrine Ørskov; Pierre Larraufie; Richard G. Kay; Frank Reimann; Fiona M. Gribble; Bolette Hartmann; Kirstine N. Bojsen-Møller; Sten Madsbad; Nicolai J. Wewer Albrechtsen; Jens J. Holst
Publié dans: International Journal of Obesity, Numéro 14, 2020, Page(s) 1859-1871, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.17863/cam.56634

Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine.

Auteurs: Valeria Booz; C. Christiansen; Rune E. Kuhre; Monika Yosifova Saltiel; Giovanna Sociali; Nicola Schaltenberg; Alexander W. Fischer; Joerg Heeren; Elena Zocchi; Jens J. Holst; Santina Bruzzone
Publié dans: Diabetes & Metabolism, Numéro 2, 2018, ISSN 2233-6079
Éditeur: Korean Diabetes Association
DOI: 10.1002/dmrr.3102

The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery.

Auteurs: Martinussen C, Veedfald S, Dirksen C, Bojsen-Møller KN, Svane MS, Wewer Albrechtsen NJ, van Hall G, Kristiansen VB, Fenger M, Holst JJ, Madsbad S.
Publié dans: Am J Physiol Endocrinol Metab, 2020, ISSN 1548-9213
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00023.2020

Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.

Auteurs: Boer GA, Hunt JE, Gabe MBN, Windeløv JA, Sparre-Ulrich AH, Hartmann B, Holst JJ, Rosenkilde MM.
Publié dans: Br J Pharmacol., 2022, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.15894

Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study

Auteurs: Meyer-Gerspach AC, Drewe J, Verbeure W, Roux CWL, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Wölnerhanssen BK.
Publié dans: Nutrients, 2021, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13010174

Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms.

Auteurs: Modvig IM, Kuhre RE, Jepsen SL, Xu SFS, Engelstoft MS, Egerod KL, Schwartz TW, Ørskov C, Rosenkilde MM, Holst JJ
Publié dans: Am J Physiol Endocrinol Metab, 2021, ISSN 1548-9213
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00026.2021

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5.

Auteurs: Samuel A.J. Trammell; Jens S. Svenningsen; Jens J. Holst; Matthew P. Gillum; Rune E. Kuhre
Publié dans: Molecules, Vol 25, Iss 2371, p 2371 (2020), Numéro 1, 2020, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25102371

Early effects of Roux-en-Y gastric bypass on dietary fatty acid absorption and metabolism in people with obesity and normal glucose tolerance.

Auteurs: Hindsø M, Bojsen-Møller KN, Kristiansen VB, Holst JJ, van Hall G, Madsbad S.
Publié dans: Int J Obes, 2022, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-022-01123-1

Glucose- and Bile Acid-Stimulated Secretion of Gut Hormones in the Isolated Perfused Intestine Is Not Impaired in Diet-Induced Obese Mice.

Auteurs: Hunt JE, Holst JJ, Jepsen SL.
Publié dans: Frontiers in Endocrinoly (Lausanne), 2022, ISSN 1664-2392
Éditeur: Lausanne
DOI: 10.3389/fendo.2022.884501

Colonic lactulose fermentation has no impact on glucagon-like peptide-1 and peptide-YY secretion in healthy young men.

Auteurs: C. Christiansen; Simon Veedfald; Simon Veedfald; Bolette Hartmann; Astrid Marie Gauguin; Søren Møller; Søren Møller; Thomas Moritz; Sten Madsbad; Jens J. Holst
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 1, 2022, Page(s) 77-87, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab666

Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1.

Auteurs: Sara L. Jepsen; Esben Thyssen Vestergaard; Pierre Larraufie; Fiona M. Gribble; Frank Reimann; Jens Otto Lunde Jørgensen; Jens J. Holst; Rune E. Kuhre
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 1, 2019, Page(s) 266–275, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgz046

New Lessons from the gut: Studies of the role of gut peptides in weight loss and diabetes resolution after gastric bypass and sleeve gastrectomy

Auteurs: Jens Juul Holst, Sten Madsbad, Kirstine Nyvold Bojsen-Mller, Carsten Dirksen, Maria Svane
Publié dans: Peptides, Numéro 176, 2024, Page(s) 171199, ISSN 0196-9781
Éditeur: Elsevier BV
DOI: 10.1016/j.peptides.2024.171199

Effect of Meal Texture on Postprandial Glucose Excursions and Gut Hormones after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Auteurs: Nora Hedbäck, Morten Hindsø, Kirstine Nyvold Bojsen-Møller, Adelaide Elise Kjær Linddal, Nils Bruun Jørgensen, Carsten Dirksen, Andreas Møller, Viggo Bjerregaard Kristiansen, Bolette Hartmann, Jens Juul Holst, Maria Saur Svane, Sten Madsbad
Publié dans: Frontiers in Nutrition, 2022, ISSN 2296-861X
Éditeur: Frontier
DOI: 10.3389/fnut.2022.889710

On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat

Auteurs: Rune E. Kuhre, Charlotte B. Christiansen, Monika Y. Saltiel, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Publié dans: Physiological Reports, Numéro 5/23, 2017, Page(s) e13507, ISSN 2051-817X
Éditeur: Wiley Periodicals, Inc.
DOI: 10.14814/phy2.13507

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

Auteurs: Charlotte Bayer Christiansen, Maria Buur Nordskov Gabe, Berit Svendsen, Lars Ove Dragsted, Mette Marie Rosenkilde, Jens Juul Holst
Publié dans: American Journal of Physiology-Gastrointestinal and Liver Physiology, Numéro 315/1, 2018, Page(s) G53-G65, ISSN 0193-1857
Éditeur: American Physiological Society
DOI: 10.1152/ajpgi.00346.2017

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Auteurs: Rune E. Kuhre, Nicolai J. Wewer Albrechtsen, Olav Larsen, Sara L. Jepsen, Emilie Balk-Møller, Daniel B. Andersen, Carolyn F. Deacon, Kristina Schoonjans, Frank Reimann, Fiona M. Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst
Publié dans: Molecular Metabolism, Numéro 11, 2018, Page(s) 84-95, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.03.007

Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss

Auteurs: Jens Juul Holst, Sten Madsbad, Kirstine N. Bojsen-Møller, Maria Saur Svane, Nils Bruun Jørgensen, Carsten Dirksen, Christoffer Martinussen
Publié dans: Surgery for Obesity and Related Diseases, Numéro 14/5, 2018, Page(s) 708-714, ISSN 1550-7289
Éditeur: Elsevier BV
DOI: 10.1016/j.soard.2018.03.003

Neuromedin U Does Not Act as a Decretin in Rats

Auteurs: Rune Ehrenreich Kuhre, Charlotte Bayer Christiansen, Seyed Mojtaba Ghiasi, Maria Buur Nordskov Gabe, Patricia Almine Skat-Rørdam, Ida Marie Modvig, Thomas Mandrup-Poulsen, Reidar Albrechtsen, Mette Marie Rosenkilde, Bolette Hartmann, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst
Publié dans: Cell Metabolism, Numéro 29/3, 2019, Page(s) 719-726.e5, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2018.10.008

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Auteurs: Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann
Publié dans: Cell Systems, Numéro 7/6, 2018, Page(s) 601-612.e3, ISSN 2405-4712
Éditeur: Cell Press
DOI: 10.1016/j.cels.2018.10.012

Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

Auteurs: Maria S. Svane, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Carsten Dirksen, Jan L. Madsen, Søren Reitelseder, Lars Holm, Jens F. Rehfeld, Viggo B. Kristiansen, Gerrit van Hall, Jens J. Holst, Sten Madsbad
Publié dans: Gastroenterology, Numéro 156/6, 2019, Page(s) 1627-1641.e1, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.01.262

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Auteurs: Charlotte Bayer Christiansen, Samuel Addison Jack Trammell, Nicolai Jacob Wewer Albrechtsen, Kristina Schoonjans, Reidar Albrechtsen, Matthew Paul Gillum, Rune Ehrenreich Kuhre, Jens Juul Holst
Publié dans: American Journal of Physiology-Gastrointestinal and Liver Physiology, Numéro 316/5, 2019, Page(s) G574-G584, ISSN 0193-1857
Éditeur: American Physiological Society
DOI: 10.1152/ajpgi.00010.2019

Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion

Auteurs: Christoffer Martinussen, Kristine Nyvold Bojsen-Møller, Carsten Dirksen, Maria Saur Svane, Viggo Bjerregaard Kristiansen, Bolette Hartmann, Jens Juul Holst, Sten Madsbad
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 104/8, 2019, Page(s) 3233-3244, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/jc.2018-02661

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Auteurs: Rune E. Kuhre, Jens J. Holst
Publié dans: Journal of Visualized Experiments, Numéro 144, 2019, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/58533

Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery.

Auteurs: Kandel D, Bojsen-Møller KN, Svane MS, Samkani A, Astrup A, Holst JJ, Madsbad S, Krarup T.
Publié dans: Am J Clin Nutr., 2019, ISSN 1938-3207
Éditeur: American Society for Nutrition
DOI: 10.1093/ajcn/nqy310

GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.

Auteurs: Geke Aline Boer; Stacey N Keenan; Paula M. Miotto; Jens J. Holst; Matthew J. Watt
Publié dans: American Journal of Physiology, Numéro 1, 2021, ISSN 0193-1849
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00646.2020

Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

Auteurs: Eiken A, Fuglsang S, Eiken M, Svane MS, Kuhre RE, Wewer Albrechtsen NJ, Hansen SH, Trammell SAJ, Svenningsen JS, Rehfeld JF, Bojsen-Møller KN, Jørgensen NB, Holst JJ, Madsbad S, Madsen JL, Dirksen C
Publié dans: Int J Obes (Lond), 2020, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-020-0578-7

Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice

Auteurs: Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ.
Publié dans: Am J Physiol Endocrinol Metab., 2019, ISSN 0193-1849
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00239.2019

Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes

Auteurs: Jørgensen NB, Bojsen-Møller KN, Dirksen C, Martinussen C, Svane MS, Kristiansen VB, Holst JJ, Madsbad S.
Publié dans: Sci Rep., 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-51516-y

Oxyntomodulin and Glicentin May Predict the Effect of Bariatric Surgery on Food Preferences and Weight Loss.

Auteurs: Mette S. Nielsen; Christian Ritz; Nicolai J. Wewer Albrechtsen; Jens J. Holst; Carel W. le Roux; Carel W. le Roux; Anders Sjödin
Publié dans: The Journal of Clinical Endocrinology & Metabolism, Numéro 1, 2020, Page(s) e1064–e1074, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgaa061

The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion

Auteurs: Anna Pii Hjørne; Ida Marie Modvig; Jens Juul Holst
Publié dans: Metabolites, Numéro 1, 2022, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12050420

Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals.

Auteurs: Martinussen C, Svane MS, Bojsen-Møller KN, Jensen CZ, Kristiansen VB, Bookout AL, Jørgensen SB, Holst JJ, Wewer Albrechtsen NJ, Madsbad S, Kuhre RE.
Publié dans: Am J Physiol Endocrinol Metab, 2021, ISSN 1548-9213
Éditeur: American Physiological Society
DOI: 10.1152/ajpendo.00190.2021

Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors.

Auteurs: Ida M. Modvig; Rune E. Kuhre; Jens J. Holst
Publié dans: Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019), Numéro 1, 2019, ISSN 2051-817X
Éditeur: Physiological Reports
DOI: 10.14814/phy2.14056

Conference proceedings (2)

Beta cell function and sensitivity to incretins before and after Rouxen-Y gastric bypass in patients with type 2 diabetes

Auteurs: Svane, MS (Svane, M. S.) [1] ; Hindso, M (Hindso, M.) [1] ; Martinussen, C (Martinussen, C.) [1] ; Dirksen, C (Dirksen, C.) [1] ; Jorgensen, NB (Jorgensen, N. B.) [1] ; Hartmann, B (Hartmann, B.) [2] ; Kristiansen, VB (Kristiansen, V. B.) [1] ; Holst, JJ (Holst, J. J.) [2] ; Bojsen-Moller, KN (Bojsen-Moller, K. N.) [1] ; Madsbad, S (Madsbad, S.
Publié dans: 2022
Éditeur: EASD annual meeting 2022

Effect of Ghrelin on Glucose Tolerance after Sleeve Gastrectomy

Auteurs: Hedback, N (Hedback, Nora) ; Dichman, ML (Dichman, Marie-Louise) ; Dirksen, C (Dirksen, Carsten) ; Bojsen-Moller, KN (Bojsen-Moller, Kirstine N.) ; Jorgensen, NB (Jorgensen, Nils B.) ; Hindso, MG (Hindso, Morten G.) ; Kristiansen, VB (Kristiansen, Viggo B.) ; Holst, JJ (Holst, Jens J.) ; Svane, MS (Svane, Maria S.) ; Madsbad, S (Madsbad, Sten, Sr.)
Publié dans: 2022
Éditeur: EASD annual meeting